Dr. Mohammed Rachidi
Dr. Mohammed Rachidi received his PhD/ Doctorate degree in Human and Molecular Genetics (with High Honors) from Pasteur Institute (Paris, France) and University Paris 7 Denis Diderot, where he studied the Cellular and Molecular Mechanisms underlying Brain morphogenesis, Visual System development, CaMKinases and Biological Clock function in Drosophila. Dr. Rachidi extended these molecular genetics works to Functional Genomics at Pasteur Institute and also at Center National of Research Scientific CNRS and played instrumental roles in different collaborative research projects with prestigious laboratories in Europe, Japan and United States. Remarkably, Dr. Rachidi collaborated with the Professor Michael ROSBASH (Nobel Prize in Physiology/Medicine 2017) in the Molecular Mechanisms of 2 genes involved in Circadian Clock. Dr. Rachidi published with Professor ROSBASH this important work in the EMBO Journal entitled : ''A New Gene encoding a putative Transcritpion Factor Regulated by the Drosophila Circadian Clock''. Assistant Professor with Professor Nicole LeDouarin at College De France and Institute of Cellular & Molecular Embryology (Nogent, Paris), Dr. Rachidi studied some Chicken and Xenopus molecules acting in Bone Morphogenetic Protein BMP signaling pathways and identified their Mouse & Human homologs involved in the differentiation of specific domains of neuronal progenitors, in the cerebellum development and Joubert syndrome (a form of the cerebellar ataxia). These experiences of Dr. Rachidi in the Molecular Genetics and in several Animal Models were extended to Human Molecular Genetics of Down syndrome (DS) and to Molecular and Cellular Mechanisms underlying Brain morphogenesis of Trisomic & Transgenic mouse models of DS and also of numerous stages of Embryonic & Fetal DS patients to elucidate the Neurogenetic Basis of Functional alterations Associated with Mental Retardation. Dr. Rachidi has vast experiences with different Research Interests in Modern Molecular Genetics, Neuroscience & Biomedical Research, to name a few : Cellular & Molecular Mechanisms underlying Brain morphogenesis, Visual System, Biological Clock, Synaptic protein Targeting, Synaptic Plasticity, CaMKII & CAMGUK/MAGUK, Learning and Memory. Functional Genomics & Mechanisms controlling Transposition at Cell Cycle. Transcription, Protein Translation & Virus-Like Particle formation. Bone Morphogenetic Protein signaling pathways, Mouse and Human homeobox genes, Cell fate determination and differentiation, Neuronal progenitors in cerebellum development and Joubert syndrome. Trisomy 21, Intellectual Disability, Candidate genes, Expression studies, Genotype-Phenotype associations, Trisomic and Transgenic mouse models of Down syndrome, Neurogenetic and Neurocognitive Basis of Functional Impairments Associated with Intellectual Disability. Dr. Rachidi realized numerous Discovery and Innovation to name a few: (1) Discovery of Quantitative Assessment of Gene Expression (QAGE) as a New Method detecting differential overexpression of candidate gene for mental retardation in Down syndrome brain regions. (2) New Cerebellar Phenotypes in Transgenic mouse in vivo Library of Human Down syndrome Critical Region. (3) Discovery of a Novel Microscopy Technology as Powerful Tool in Neuroscience and Biomedical Research. Dr. Rachidi published numerous articles in international peer-reviewed journals like EMBO, Genomics, DNA Research, Gene, Mechanisms of Development, Cytogenetics & Genome Research, Neuroscience Research, International Journal of Developmental Neuroscience, Cell Tissue Research, American Journal of Intellectual Developmental Disability, European Journal of Paediatric Neurology....and numerous journals of Elsevier & Springer. Dr. Rachidi has been honoured worldwide as Invited Distinguished Speaker, Chairman or Invited Honourable Organizing Committee Member in numerous International Conferences, Seminars and Workshops in Europe, USA and Asia. Dr Rachidi received numerous Awards, Honors and he is an Editor in numerous International peer-reviewed Journals.